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In the early decades of the 1900s, Durham acquired national reputation for entrepreneurship. Businesses owned by African Americans lined Parrish Street. Among them were N.C. Mutual Life Insurance Co. (moved to Parrish, 1906), led by John Merrick, Dr. Aaron Moore, & C. C. Spaulding, and Mechanics and Farmers Bank (1907), led by R. B. Fitzgerald and W. G. Pearson.
During the 1920s-1940s, Durham was home to African American musicians whose work defined a distinctive regional style. Blues artists often played in the surrounding Hayti community and downtown tobacco warehouse district. Prominent among these were Blind Boy Fuller (Fulton Allen) (1907-1941) and Blind Gary Davis (1896-1972), whose recordings influenced generations of players.